Radboud University Medical Center

Department of Geriatric Medicine


TOPICS-MDS allowed for the construction of a validated composite endpoint (CEP), which integrates information from several domains into an index. The TOPICS-CEP combines the eight components from TOPICS-MDS, into one (preference-) weighted index. More information can be found in the TOPICS-CEP Guidelines Version 1.1 and in the following articles:



1. Hofman CS, Makai P, Blom JW, Boter H, Buurman BM, Olde Rikkert MG, Donders R, Melis RJ. Comparing the health state preferences of older persons, informal caregivers and healthcare professionals: a vignette study. PLoS One. 2015 Mar 4;10(3):e0119197. doi: 10.1371/journal.pone.0119197.


2.Hofman CS, Makai P, Boter H, Buurman BM, de Craen AJ, Olde Rikkert MG, Donders R, Melis RJ. Establishing a composite endpoint for measuring the effectiveness of geriatric interventions based on older persons’ and informal caregivers’ preference weights: a vignette study. BMC Geriatr. 2014 Apr 18;14:51. doi: 10.1186/1471-2318-14-51